Brazilian wasp venom as a cure for cancer: mechanism of action and effectiveness of the drug

The Brazilian wasp gained worldwide fame after scientists from Brazil and the USA published information that the venom of the Brazilian wasp kills cancer cells. Insects belong to the subfamily of common wasps, paper wasps, and social wasps. The most numerous, extensive family in terms of the number of species. The venom of the Brazilian wasp Polybia paulista contains a unique peptide, Polybia-MP1 (MP1), which can destroy some cancer cells.

Brazilian wasp - cancer winner

At the end of the last decade, one of the UK universities substantiated the assumption that the venom of the Brazilian wasp Polibia Paulista has such a peculiarity of its effect on the cells of the human body when introduced, which is characterized by a special “interest” of some of its components in cancer cells.
According to Paul Beals, who with his team of scientists made this discovery, experiments with the introduction of poison from this species living in Brazil gave the following result.

It turned out that the venom of the Brazilian wasp kills cancer cells, literally tearing them apart, while not having any harmful effect on healthy cells.

The principle of this unique behavior of the toxin is explained by its desire to come into contact with fats such as phosphatidylserine and phosphatidylethanolamine, which usually appear as a second ball around the tumor cell.

Reproduction

Genetically, leaf-cutter ants are characterized by a diploid chromosome set - 2n = 38. Reproduction occurs similarly to other species of ants. At a certain stage, the caste of worker ants begins to fatten the larvae with the addition of special substances that stimulate sexual development. Females and males adapted for reproduction have wings. As soon as the number of such individuals reaches critical values, they fly out of the anthill, begin to swarm and mate.

Leaf cutters are not characterized by polygyny and therefore there is always only one queen in the anthill.

Some species of leaf-cutter ants have amazing abilities. In the event of the death of the only queen, the function of laying eggs is taken over by the workers. In this case, in some species, eggs produce males that are unable to perform the reproductive function, while in others, absolutely normal individuals emerge.

To collect a sufficient amount of seed, a swarming female mates with several males at once. Swarming lasts one day and ends with the death of the males. The female begins the process of oviposition in a hole dug by her. Several chewed and mycelium-infected leaves are also placed there. After 40–60 days, the first brood of working individuals appears, which take on all the “routine” work.

Brazilian wasp: description and photo

This is what she is, the Brazilian wasp. If it stings, it won’t seem too bad to anyone.

Polybia paulista, or the Brazilian wasp, is a type of social paper wasp, meaning it lives in groups rather than alone, and builds nests from plant fibers. They live in South America - in Paraguay, Argentina and Brazil (mostly here, especially in Sao Paulo).

The number of Brazilian wasp colonies ranges from 4.5 to 13 thousand individuals. Up to three colonies can peacefully coexist on one territory. Unlike bee families, they have many queens (10-100 pieces), and they get along well together. When mating, the queen of the Brazilian wasp stores sperm inside and uses it when she needs to fertilize the eggs. During the hatching of the larvae, all construction work is stopped in order to use all resources for the young animals. Working individuals fly out already on the 6th day after hatching.

The Brazilian wasp has a division of labor according to age - the riskiest work goes to the oldest members of the family. Different groups of wasps build the nest, collect food, raise their young, and protect the nest from predators and parasites. Brazilian wasps fly to collect food at temperatures ranging from 19.5 to 37°C. The higher the temperature, the more wasps fly to get food. Not so much food as water to cool the nest, since worker wasps cannot cope with flapping their wings alone.

Wasps also collect plant fiber to repair the hive, usually in August-September and December-January. The larvae are fed animal protein, they themselves feed on carbohydrates, and they prefer cacti to all plants.

It would seem that they are ordinary, unremarkable insects, with the exception of some properties of the venom of the Brazilian wasp. Unlike the venom of ordinary wasps we are all familiar with, it is truly medicinal and not just irritating.

Lifestyle

The flight of German wasps is observed from May to the end of August.
Adult insects feed on thistle, forest angelica. This is additional nutrition; after emerging from the pupa, the supply of nutrients is enough for 2 weeks. Males prefer sweet plant secretions. Females are found less often on flowers, but they are also not averse to tasting nectar. Wasps are not active throughout the day; they are active 4-5 hours a day. The ability of German wasps to inflict painful stings with their stings gave rise to various names “cow killer” and “mule killer”. In fact, insect venom is not enough to harm large animals. Red spots in the color of wasps warn others about its danger. The number of insects is affected by environmental pollution and negative changes in habitats. The European German species is listed in the Red Book of the Smolensk region. The number of insects in the region is still at a sufficient level, but there is a downward trend.

Features of reproduction

The European bird does not build its own nests, but is a parasitoid of lepidopteran and hymenopteran insects. Most often, wasps lay eggs on bumblebee larvae. Sometimes German bees attack honey bees Apis mellifera. Females run along the ground in search of the host’s nests; she uses sensitive antennae for location. They penetrate into the dwellings where the larvae have appeared and lay their eggs on them. After 3-4 days, the offspring of German females appear. The first instar larva has mandibles strong enough to gnaw through the host's integument (usually in the chest area) and begin feeding.

The host is completely eaten; the size of the future wasp depends on its size. The Germans who fed on bees were smaller than the insects that developed on bumblebees. Parasitoids overwinter at the pupal stage. They create their own cocoon inside the host. In spring, adults gnaw their way out. The males appear first and make frequent flights in search of females to mate with. During this period they feed on nectar. For females, it is more typical to suck the bodies of killed insects. Insects lead a secretive lifestyle, making them difficult to observe.

Preparations based on Brazilian wasp venom

Ready-made medications have not yet been created, since the mechanism of action of the Brazilian wasp venom was discovered only in 2015, and has not even reached the stage of clinical trials.

One reason is that it is not the entire poison that cures, but a peptide that is not easy to extract:

1. Brazilian wasps are frozen and stored at −20 ◦C.
2. The venom reservoirs are removed using microsurgical scissors and washed with a solution of acetonitrile and water containing 0.1% trifluoroacetic acid to dissolve the peptides.
3. The extract is then purified in a centrifuge at 8000 × g for 15 minutes at 4°C.
4. The supernatant (formed on top as a result of settling) is collected for further purification of the peptide.
5. It is chromatographed under special conditions for an hour, then dried in a lyophilizer and chromatographed again, but with a reverse phase.

Not an easy process, right? As a result, the medicinal substance turns out to be barely one hundredth of the total mass of the poison.

The exact dosage of the poison has not yet been clarified. In one experiment, it was found that at a concentration of 4.5 × 10−5 M the peptide caused the dissolution of 50 microliters of malignant cells. In others, it was discovered that the minimum concentration of the peptide to suppress different infections is different:

• Escherichia coli and Pseudomonas aeruginosa - 8 mu g/mL,
• Bacillus subtilis – 4 mu g/mL,
• Staphylococcus aureus – 15 mu g/mL

Even if you delve into the available studies and calculate the approximate dose from them, it remains unclear how to administer the drug, because during the experiment the peptide acted directly on the membrane - “watered” it. How to ensure such contact in the body if the disease is in the bladder or prostate gland?

Schmidt scale

This led Justin to create his own pain scale for venomous insects, also known as the Schmidt Sting Severity Scale. There are four points on it, and it is based on the sting of an ordinary bee, which is familiar to almost everyone. A bee sting is worth two points. To be rated a point lower or higher, the bite must differ significantly in pain. If it is not different enough, it is assigned half the value.

Over many years of research, the entomologist added many more species of insects to his list, not only ants, but also bees, wasps and others. Of course, Schmidt was never particularly keen to experience the bites and effects of the venom of these insects, but in the course of his research he received more than a thousand bites from 83 species of stinging insects. It is not surprising that not only ordinary people, but also fellow entomologists listen to the words of such an expert.

Healing poison

The venom of the Brazilian wasp may soon become a new medicine in the fight against cancer. More recently, it turned out that the venom of these particular wasps has such healing properties. They live only in Brazil. The bottom line is that the poison does not have its toxic effect on all affected areas.

The venom of the Polybia Paulista wasp contains the Polybia-MP1 peptide. It acts on some areas of the body affected by malignant neoplasms. First of all, these are prostate cancer cells, leukemia, and a malignant tumor of the bladder. These malignant neoplasms are very resistant to many medications.

Biology

The biology of polystines is very diverse. Some species (for example, representatives of the genus Polistes) have very primitive behavior. Polists build a nest in the form of a single open honeycomb; the number of wasps in such nests is small - from 10-15 to a little more than 100 wasps. Polistes nests are often founded by a single female (or less commonly by a group of females). Others (for example, wasps of the genus Polybia) are characterized by very complex behavior. Polybia build complex nests, with many layers of honeycombs. These nests are often home to thousands of active worker wasps, and new nests are founded in swarms. In addition, representatives of this subfamily also hold the record for the number of wasps in one colony: for example, Agelaia vicina (South America) can have more than 1,000,000 wasps in one nest.

According to the type of founding of new colonies, two groups are distinguished: independent founding by one or a group of females without the participation of working individuals (Polistes, Mischocyttarus, Belonogaster, Parapolybia, and part of the Ropalidia species) or budding by swarming (about 20 genera of the tribe Epiponini, genus Polybioides, part of the Ropalidia species ).

In the tribe Epiponini, a wide range of variants of queen-worker dimorphism is observed:

1. The absence of morphological differences between queens and workers throughout the life cycle of the colony (Parachartergus smithii, Pseudopolybia vespiceps, Chartergellus communis, Brachygastra lecheguana).
2. No morphological differences between castes, but some young females develop ovaries only during some phases of the colony cycle (Synoeca cyanea)
3. There are morphological differences between castes, varying during the colonial cycle, with unfertilized oviparous females in the final period of the colonial cycle (Protopolybia exigua and Protopolybia sedula)
4. Caste differences increase during the colonial cycle with unfertilized females appearing only during some phases of colony development (Chartergus globiventris, Polybia scutellaris, Polybia occidentalis, Polybia paulista, Protonectarina sylveirae, Epipona guerini)
5. Queens always differ from workers, and these differences do not vary during the life of the colony (Agelaia areata, Agelaia vicina, Agelaia pallipes, Agelaia multipicta, Apoica flavissima, Apoica pallens, Polybia dimidiata).

Literature

Key to insects of the European part of the USSR. T. III. Hymenoptera. First part // Suborder Apocrita - Stalk-bellied (Arnoldi K.V. et al.) / under the general. ed. G. S. Medvedeva. - L.: Nauka, 1978. - P. 71–83 (Supersem. Mutillioidea - Lelei A.S.). — 584 p. — (Key guides to the fauna of the USSR, published by the Zoological Institute of the USSR Academy of Sciences; issue 119). — 3500 copies.

• Key to insects of the Russian Far East. T. IV. Reticuloptera, Scorpioptera, Hymenoptera. Part 1 / under general ed. P. A. Lera. - St. Petersburg: Nauka, 1995. - P. 202-211 (Fam. Mutillidae - Germans, or mutillids - Lelei A.S.). — 606 p. — 3150 copies. — ISBN 5-02-025944-6.
• Lelei A. S.
  German wasps (Hymenoptera, Mutillidae) of the fauna of the USSR and neighboring countries. - L.: Nauka, 1985. - 268 p. — 1000 copies.
• Leley A. S.
  Catalog of German wasps (Hymenoptera, Mutillidae) of the Palearctic region. - Vladivostok: Dalnauka, 2002. - 171 p. — ISBN 5–8044–0280–3.
• Leley A. S.
  Catalog of German wasps (Hymenoptera, Mutillidae) of the oriental region. - Vladivostok: Dalnauka, 2005. - 251 p.
• Leley A. S., Kabakov O. N. (1980). To the knowledge of wasps of the families Bradynobaenidae and Mutillidae (Hymenoptera) of Afghanistan
  // Entomological Review. - T. 59. Issue. 1. pp. 181-196.
• Brothers, D. J. (1975). Phylogeny and classification of the aculeate Hymenoptera, with special reference to Mutillidae.
  // University of Kansas Science Bulletin 50: 483–648.
• Manley, D. G. and J. P. Pitts. (2002). Key to the genera and subgenera of Mutillidae of America North of Mexico.
  Journal of Hymenoptera research. 11: 72-101.
• Manley, D. G. and J. P. Pitts. (2007). Revision of the Neotropical velvet ants of the genus Dasymutilla (Hymenoptera: Mutillidae).
  Zootaxa, 1487, 1-128.
• Nonveiller, G. Catalog of the Mutillidae.
  Myrmosiciae and Bradynobaenidae of the Neotropical Region inclnding Mexico (Insecta: Hymenoptera). SPB Academic Publishing bv, the Netherlands, pp. 1–150.
• Pitts, J. P. (2007). Revision of Odontophotopsis Viereck (Hymenoptera: Mutillidae), Part 1, with a description of a new genus Laminatilla
  . Zootaxa, 1619: 1-43

Classification

The polystinia subfamily is divided into 4 tribes, including 25 genera and more than 800 species.

The genus Euparagia Cresson, 1879 belongs to a separate subfamily Euparagiinae

.

• Polistinae
  Tribe Polistini Polistes Latreille, 1802

Effect of poison

Scientists from the University of Leeds, which is located in the UK, have long learned that wasp peptide can destroy a malignant tumor. So they began an in-depth study of the venom of the Brazilian wasp. Paul Beals and some other British scientists understood why such an amazing reaction to wasp venom occurs. MP1 poison peptides interact well with lipids - fatty acids that supply cells with energy and form the membranes of healthy cells. The venom of the Brazilian wasp kills cancer cells by damaging the upper membrane and forming cuts in it, through which tumor cells can interact with healthy ones and be supplied with oxygen. In this case, no harm is caused to an ordinary functioning cell. The difference is that in a healthy cell the inner layer consists of phosphatidylserine and phosphatidylethanolamine, while in a cancerous cell it acts as the outer layer.

Discovery of the unique properties of poison

The wasp Polybia paulista has been discovered in Brazil. They are called polystins. A fairly impressive group of insects is a member of a subfamily of paper wasps called social wasps. Behavior differs from other individuals of this class.

Brazilian wasps build unusual honeycombs with multiple exits.

However, it was not the home of biting insects that attracted the attention of scientific luminaries. Recently, scientists have begun studying the poison in the sting.

The research work was carried out not in America, where unusual healers live, but in Britain. The discovery belongs to the English scientist Paul Beals.

He and his colleagues established that the venom of the Brazilian wasp is a medicine due to the presence of the Polybia-MP1 peptide in it.

It has been proven that the toxic substance has healing properties. It consists of molecules that can influence cancer formations.

Such a promising statement caused a heated debate. Scientists from other countries and patients hoping to overcome the disease joined the discussion.

Fraudsters who are ready to immediately sell the medicine did not remain indifferent either.

They said that a potent drug was already ready. The network began to sell the venom of the Brazilian wasp - a cure for cancer that guarantees complete healing.

Mechanism of action of Brazilian wasp venom

The peptides contained in wasp venom destroy malignant cells. The process was observed at the molecular level.

In a normal state, cells have a complex structure. There are two fat layers with different structures.

As the tissue develops into malignant, the composition of the layers changes. The molecules that form the inner membrane move involuntarily into the outer layer.

Gradually, an excess amount of phosphaditylethanolamine and phosphaditylserine is formed on the surface of the cancer cell.

A peptide extracted from wasp venom rushes to where the specified components are found.

At the points where the peptide molecules adhere to the cells, pores appear, which scientists conventionally call holes. As they increase, the strength of the cells weakens, but peptides continue to accumulate intensively on the surface.

As a result, the shell first weakens, then cannot withstand it and breaks. The contents of the malignant cell spread. She is slowly dying.

The effect of peptides on the body is recognized as amazing. They connect exclusively with malignant cells, without touching healthy ones at all. The discovered fact was considered significant.

Based on insect venom, scientists are developing a medicine that can spare healthy cells, completely destroying malignant ones. The amazing difference between a natural product and chemotherapy.

Efficiency and cost of a drug based on Brazilian wasp venom

The venom of the Brazilian wasp kills cancer cells - although not all, but some. It is effective in the presence of malignant tumors of the prostate, blood, and bladder.

British scientists continue to further study the poison. They are confident that very soon they will be able to create a powerful medicine that can defeat oncology.

The main component will be the Polybia-MP1 peptide.

It is too early to talk about the cost of the drug. However, it is clear that the price will be appropriate. They plan to use natural ingredients for production.

Conclusion

Pharmacology is developing rapidly. Testing of the venom of the Brazilian wasp has been going on for almost a decade.

I would like to hope that a drug will appear that will make oncology retreat. The world is waiting, because the venom of the Brazilian wasp kills cancer cells. This is a fact proven by scientists.

Video: Brazilian wasp venom kills cancer!

Is Brazilian wasp venom a cure for cancer?

Today we will touch upon a rather unusual topic for the ear and eyes, which involves an analysis of the possible beneficial properties of wasp venom for humans. After all, many have heard about the healing properties of bee venom, but few know that a wasp sting can also be associated in the future with benefits for human health.

So, in this article we will analyze the overt harm of a wasp sting, and the hidden benefit of the action of the poison of some types of wasps on the human body, which we have yet to hear about in practice in the future. And find out whether the venom of the Brazilian wasp can help fight cancer!

Chemical composition of wasp venom

Before we talk about the revolutionary discoveries of the future, let's just go over all the main components that make up the venom of most wasps.

So, the venom of a common paper wasp has the following main components, namely:

• histamine;
• acetylcholine;
• serotonin;
• phospholipases A and B;
• hyaluronidase.

Everyone has heard the word “antihistamine.” Antihistamines are usually medications that are specifically designed to reduce the very dangerous effect of a substance such as histamine in the body.

Histamine is found in every cell of our body initially. Usually this substance is in an inactive state and does not manifest itself in any way until a certain moment.

But, when cellular receptors are triggered or cells are destroyed, this mediator may be released to increase the immune system’s response to the penetration of a foreign chemical compound into the body.

Simply put, what is commonly called an allergic reaction of the body occurs. With all the possible consequences that arise from this. The venom of some wasps, the same hornets, not only contains histamine, but also destroys the structure of cells, releasing a clogged mediator, creating a greater threat of anaphylactic shock.

Acetylcholine and serotonin are neurotransmitter enzymes. Acetylcholine is responsible for the severe, sharp pain that a person feels after receiving a portion of poison after being stung by a wasp. This substance activates all sensory receptors and nerve endings at the site of the bite as quickly as possible, which is why we feel the bite so painfully.

Serotonin is also called the “hormone of happiness” and this substance is found not only in wasp venom, but also in human cells. Its excess in the body catalyzes such unpleasant manifestations as rapid heartbeat, vascular spasm, as well as pain at the site of the bite.

Phospholipases are precisely the same enzymes that can destroy the walls of cell membranes and, thereby, release mediators contained there, such as histamine and serotonin, provoking a significant increase in the response of the body’s immune system to the penetration of poison into the bloodstream.

Hyaluronidase has a similar effect to phospholipases, also destroying tissues and cells, and also provokes an inflammatory process at the site of the sting.

From here we will further talk about the harm and possible benefits of wasp venom for human health, because, as you know, every action has its reaction. And perhaps everything is not so simple with wasp poison, the correct use of the properties of which will bring great benefit to humanity in the future.

Harm of wasp poison

But, before we talk about the secret and hidden, let's talk about the obvious. It's no secret that the bite of wasps, and hymenoptera in general, poses a considerable danger to human health. You can verify this in advance by reading the information from the previous chapter of our review about the composition of the venom of this stinging insect.

What does a person get when bitten by a Hymenoptera? Pain, inflammation, feeling unwell. And this is in the best case, if there were no complications. But it can be much worse, and this is also not news.

So, what happens when stung by an insect such as a wasp?

We list all the main symptoms and sensations, namely:

• severe sharp pain;
• bruising is noticeable in a small radius around the sting site;
• rapidly growing inflammation and swelling at the site of the bite;
• temperature rise to subfebrile levels, and sometimes higher;
• increased heart rate;
• lowering blood pressure;
• hyperhidrosis (excessive sweating) may occur;
• clouding of consciousness up to its loss.

As we can see, the picture that emerges is not a pleasant one. The sharp pain after an insect sting is explained by the entry of acetylcholine into the wound, which provokes the activation of nerve endings at the site of the bite and generates a pain response.

Bruising can occur due to the presence of enzymes in the wasp venom that dissolve small blood vessels. This is especially true for hornets.

The occurrence of swelling at the site of the sting with all the accompanying pain, as well as an increase in temperature and some other unpleasant symptoms are quite understandable. Thus, we feel the reaction of our immune system to the penetration of such a strong allergen into our body, which is the hymenoptera toxin.

If everything is limited to the above-mentioned symptoms and sensations, you can, as they say, sleep peacefully. Usually in such cases everything goes away in 2-3 days, as if it never happened.

But it’s a completely different matter if a person has a tendency to be allergic to this kind of pranks and tricks of insects. In this case, symptoms of an allergic reaction may occur, such as a noticeable decrease in blood pressure, vasospasm, skin rashes, and clouding of consciousness.

The occurrence of anaphylactic shock can lead to death, most often due to cardiac arrest. Also, in some cases, the result of the bite of several wasps, especially large species, may be the development of kidney failure.

In a word, there is no need to talk about any benefit from the wasp yet. However, perhaps not everything is so neglected. Let's finally talk about those rumors, assumptions and facts that for some time now have given the scientific community reason to say that wasps not only cause suffering, but can also save lives.

The benefits of wasp venom: fact or fiction?

After reading the previous material, you can ask yourself: what other benefit can such a vile and harmful creature bring? And you will be more right if we talk about an ordinary wasp sting in broad daylight on the street. But not everything is so simple if we talk about the properties that are hidden in the chemical composition of wasp venom, with which we began our analysis.

Firstly, the benefit of the wasp lies in the fact that its venom can and should be used as a preventive vaccination procedure. This is what is done in many countries. At the beginning of the summer, people sensitive to wasp venom are vaccinated with a small amount of purified wasp venom that is safe for allergy sufferers.

Thus, a person develops resistance, or at least increases the level of production by the immune system of those antibodies that specialize in quickly eliminating the toxins contained in insect venom.

And secondly, there is one special type of wasp, the venom of which can not only harden the human body by vaccination, but also, according to scientists, in the near future it will make it possible to save human lives by destroying cancerous tumor cells.

Brazilian wasp - cancer winner

At the end of the last decade, one of the UK universities substantiated the assumption that the venom of the Brazilian wasp Polibia Paulista has such a peculiarity of its effect on the cells of the human body when introduced, which is characterized by a special “interest” of some of its components in cancer cells.

According to Paul Beals, who with his team of scientists made this discovery, experiments with the introduction of poison from this species living in Brazil gave the following result.

It turned out that the venom of the Brazilian wasp kills cancer cells, literally tearing them apart, while not having any harmful effect on healthy cells.

The principle of this unique behavior of the toxin is explained by its desire to come into contact with fats such as phosphatidylserine and phosphatidylethanolamine, which usually appear as a second ball around the tumor cell.

Brazil nut - a powerful weapon for health

Benefits of Brazil nuts

Here is a short list of the benefits of selenium in Brazil nuts:

• Selenium helps thyroid function by converting inactive T4 (thyroid hormone) into the active form T3. Healthy thyroid function = healthy metabolism
• The antioxidant properties of selenium improve the function of vitamins E and C, which help reduce skin aging.

• Selenium is a powerful health food for men because it increases testosterone levels and improves sperm production and sperm motility.
• Selenium is important for women as a protector against breast cancer. Studies have shown that the more selenium in the diet, the lower the incidence of breast cancer.
• Selenium strengthens the immune system to protect against bacterial and viral infections.
• Selenium helps you achieve a healthy cholesterol ratio by helping to raise HDL levels and lower LDL levels.

One of the most impressive benefits of selenium was documented in a five-year study conducted at the University of Arizona and Cornell University. These data showed that patients receiving selenium saw a 63% reduction in the likelihood of prostate cancer, a 58% reduction in colon or rectal cancer, and a 46% reduction in lung cancer.

Brazil nuts can be part of an overall healthy eating plan as they contain high amounts of other essential nutrients. They are an excellent source of the antioxidant vitamin E, which is essential for maintaining cell membranes and protecting skin health.

Brazil nuts are an excellent source of several B vitamins, which range from improving brain health and boosting metabolism. You will also find large amounts of copper, magnesium, potassium, calcium and zinc in Brazil nuts. Many raw nuts have excellent health properties, but Brazil nuts are definitely at the top of the list.

Just 100g of Brazil nuts provides about 3485% of the recommended daily intake of selenium. 100g is a big handful, but you definitely don't need it! Yes, Brazil nuts and selenium can provide great health benefits, but trying to overdose can cause damage to your DNA. Two to four nuts per day is the norm.

What you need to know when buying Brazil nuts

Due to the fact that Brazil nuts are primarily protein and healthy fats, they are very susceptible to going rancid. Brazil nut fats are pure magic. They can be both beneficial to the body and harmful if the nut is not fresh. Make sure the nut is hard. When you bite into it, you should feel a buttery texture. Nuts should not smell sweet and should not be bitter! They should be stored in a cool, dry place - the refrigerator is best!

How to eat them

Of course, Brazil nuts should be consumed raw. It is important to understand that roasted nuts already have a damaged fat structure and can be harmful to your health. Published by econet.ru.

PS And remember, just by changing your consciousness, we are changing the world together! © econet

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The mechanism of cancer destruction

Molecules of a toxic substance stick to diseased cells 8 times more often than to healthy tissues. Pores or holes are created on the surface of the tissue, which allow the internal contents of the membrane to flow out. The more killer cells, the higher the therapeutic effect. The poison can kill cancer in a matter of days.

Important!

Officially, medicine has not yet developed special drugs for humans based on the venom of the Brazilian wasp or its synthetic analogues. However, scientists hope that their discovery will become the basis for creating an effective cure for cancer in the future. The advantage of this medication is the absence of side effects and safety for healthy tissues.

Wasp secretion is actively sold through websites on the Internet; the price of Brazilian wasp venom is quite high.

Alternative method

In the near future, scientific developers plan to study in great detail the effect of wasp venom peptide on cancer-affected cell membranes. They want to multiply this healing effect. To create a powerful cancer cure and a new form of safe anticancer drugs from the venom of the Brazilian wasp. This will greatly benefit patients suffering from cancer.

An alternative method of quality treatment in the fight against cancer will be an excellent addition to methods such as radiotherapy and chemotherapy, which kill not only cancer-affected areas, but also completely healthy cells.

Results and feedback on application

There have been no reviews yet from customers about the positive effects of the Brazilian wasp peptide, although they promised to unsubscribe at the beginning of the year. There are 4 reviews on the online store page, but they all say that people bought this ampoule and will use it somehow. We will wait for official clinical trials. Scientists need to prove that the body will not be harmed by wasp poison, or that the benefit will be immeasurably greater. The fight against cancer is a very promising industry and very profitable, so the creation of a cure is unlikely to be shelved.

Brazilian wasp venom kills cancer cells without damaging healthy ones « Gearmix

A new study published in the Biophysical journal shows that the venom of the Brazilian folded wasp Polybia p a ulista contains powerful anti-cancer substances. The toxin, called MP1 (Polybia-MP1), is able to kill tumor cells without affecting healthy ones.

To study the mechanism of this selective action, the research team created a model of cell membranes and exposed them to the toxin. Using biophysical methods, it was found that MP1 selectively attacks cancer cells due to the abnormal distribution of lipids (fat molecules) that are located on the outer shell of the protective membranes of tumor cells.

Substances that affect cancer cells, interacting with lipids, deform the structure of cell membranes, creating holes in them. As a result, molecules begin to leak through the membranes, and cancer cells, unable to function normally without these molecules, eventually die.

At the same time, the toxin does not harm healthy cells, since they have a different set of lipids, located not on the outer, but on the inner cell membrane.

According to University of Leeds professor Dr Paul Beals, a cancer treatment technique based on interaction with lipids in the membranes of tumor cells could lead to the creation of “an entirely new class of anti-cancer drugs”.

The toxin has been tested on prostate and bladder cancer cells and has proven effective in inhibiting their growth. It also appears to be effective against leukemia cells, which are known to be highly resistant to a number of drugs.

Wasp venom is not always dangerous

Research reported by Medical News Today has shown that the venom of one particular breed of wasp contains a powerful anti-cancer ingredient, and scientists say their experiments have shown how the toxins in the venom kill cancer cells. .

The venom of the Brazilian social wasp, called Polybia Paulista, contains the antimicrobial peptide Polybia-MP1 (MP1), which has been found in research to inhibit several forms of cancer cells, such as prostate cancer cells, bladder cancer cells and drug-resistant leukemia cells.

Although this antimicrobial peptide has previously shown great potential as an anticancer agent in humans, until now researchers did not fully understand how MP1 peptide kills cancer cells.

A new study, recently published in the Biophysical Journal, shows how MP1 kills cancer cells while leaving healthy cells completely unharmed. It turns out that this peptide attacks lipids located on the surface of cancer cells and creates holes through which important cellular molecules can leak.

Senior study author Paul Beales from the University of Leeds in the UK explains that a cancer treatment that would work by attacking the lipid cell membrane with a wasp venom-containing drug would be an entirely new class of anticancer drugs. .

The scientist believes that the new discovery will be very useful for the development of innovative methods of combination therapy, during which several drugs will be used simultaneously to treat cancer. All of these drugs will attack different parts of the cancer cells at the same time.

As the researchers assumed, the mechanism of action of the MP1 peptide on cancer cells works due to the fact that the cell membranes of cancer cells differ from healthy cell membranes.

Scientists believe that one of the main differences between cancer and healthy cells is the location of two lipids, which are parts of the cell membrane: phosphatidylserine (PS) and phosphatidylethanolamine (PE). In cancer cells, PS and PE are located on the outer cell membrane, which faces the direction from the chamber, and in healthy cells they are located in the inner membrane with the front side inward.

Tested by experience

To test their assumption, scientists conducted experimental studies. To do this, they developed a cell membrane model containing phosphatidylserine and phosphatidylethanolamine. The membrane was exposed to the MP1 peptide. Then they began to observe the effect. Experienced scientists have seen that the presence of the phosphatidylserine component helps the Brazilian wasp venom act on the cell membrane, and the combination of the phosphatidylethanolamine component with wasp venom destroys the upper layer of the cell membrane and makes small microcracks in it. Through such micropores, the affected cell begins to function normally.

results

There is no real information about how effective the poison is. Apart from high-profile discoveries and information in the magazine, there is no confirmation. It is not clear how to take the medicine, in what doses. How long is one capsule at a price of 9 thousand rubles? per piece, how long should the treatment last to notice the result.

There are reviews on various sites, but only about how much the purchase cost and how long it took to wait for the product. No effectiveness results. Whether to buy such products is an individual decision. However, if everything were so effective, the drug would be sold in official medical institutions and would be widely used in oncology therapy, which is not currently happening.

Cost, where to buy

With the help of the Internet you can buy absolutely everything, anywhere in the world. Brazilian wasp venom is sold in a special dark glass capsule to protect it from sunlight. The study, published in the pages of the Biophysical journal, created a real sensation, instilling hope in patients for a speedy recovery and cessation of the pathological process.

Brazilian wasp

Important!

The weight of one ampoule of Brazilian products is 5 ml. Application requires special care, since in large quantities the poison is deadly. Price – 9 thousand rubles. a piece. The products are supplied from Brazil, but you have to wait for the parcel for some time. Approximately a week if the product is available from official representatives in Russia, about a month if it is not currently available.